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Bringing Epigenetics To Life.
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EpiCypher® works with leaders in the field to deliver innovative solutions that meet scientists’ most challenging research needs. We have pioneered the development of modified designer nucleosomes (dNucs) and are applying these physiological substrates to develop next-generation biochemical and epigenomics technologies. As your research partner, we will provide cutting-edge tools and services for epigenetics and chromatin biology research. How can we help you Bring Epigenetics to Life?
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EpiCypher is dedicated to creating novel platforms that support innovative chromatin research.
We are constantly expanding our product lines to provide the latest in quantitative chromatin technology.
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Robust, high-resolution chromatin profiling,
at a fraction of the time andcost
of ChIP-seq
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Direct quantification of ATP-dependent chromatin remodeling enzyme activity on a defined nucleosome substrate
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Accurate ChIP-seq antibody validation and data normalization using DNA-barcoded nucleosome spike-ins
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SNAP-ChIP® spike-ins
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EpiCypher dNucs™ are semi-synthetic recombinant nucleosomes, containing one (or more) histone PTMs. Nucleosomes are the natural target of chromatin readers and modifying enzymes, and thus provide a superior substrate for epigenetic enzymes and interactor proteins
dCypher® Nucleosome Panels
dCypher® Nucleosome Panels provide unprecedented access to epigenetic diversity in a physiologically relevant nucleosome context
Recombinant Nucleosomes (rNucs)
Recombinant Nucleosomes (rNucs) are human recombinant nucleosomes comprised of histone proteins made in E. coli wrapped with fully synthetic Widom 601 DNA. As the nucleosome is the true physiologic substrate for many histone modifying enzyme, these are excellent substrates for enzyme screening assays.
EpiDyne® Chromatin Remodeling Substrates
Chromatin remodeling has been implicated in diverse diseases, including most types of cancer. The study of chromatin remodeling requires highly defined nucleosomal substrates, which are challenging to produce and adapt to various assays
Other Nucleosomes
- Oncogenic Nucleosomes (oncoNucs)
- Variant Nucleosomes (vNucs)
- Methyl DNA Designer Nucleosomes
- Purified Nucleosomes (HeLa, Avian)
- Nucleosome Components & Subunits